Enhanced CBDA Absorption for Greater Health Benefits
- On June 7, 2022
CBDA Absorption, Enhanced Health Benefits
CBDA has higher absorption than CBD1, because it has different absorption properties due to the carboxyl group in the CBDA. Why is this important? If a compound has amazing medicinal benefits, but is not absorbed well by the body, then you will need to take significant amounts of the compound to get the benefit. Did you know that epileptic patients who take CBD to control seizures take over 2000mg of CBD per day2? This is due in part to the absorption properties of CBD.
Average concentration of CBD and CBDA in blood after ingestion of equivalent amount1
What is Bioavailability?
The human body can absorb compounds through many routes, such as sublingual (under the tongue), topical (through the skin), intranasal (through the nose), and oral ingestion (eating/drinking). Depending on the molecular structure and route of administration, the body may absorb more or less of the molecule of interest. The absorption by the body is measured by taking a multiple samples of blood after administration of the compound or nutrient, and analyzing the concentration of the compound over time. The amount in the blood compared the amount of the compound administered is referred to as the Bioavailability, the higher this number, the better the compound gets into the body and can exert its medicinal effects.
Absorption of CBDA and CBD in heated and unheated hemp oil
As we have mentioned before, CBDA is the natural cannabinoid found in the hemp plant, and forms CBD only after exposure to high heat, typically seen in conventional purification processes. Natural Dos does not use heat during its purification process, allowing us to produce a Natural Spectrum Oil that contains, maintaining the high bioavailable cannabinoids. In a recent study out of Basel, Switzerland, researchers found that not heating Hemp Oil, and leaving CBDA in the mixture, increased the blood levels of CBD ~4-fold3. This surprised us, why would CBD blood levels also be increased in high CBDA mixtures compared to CBD only formulations? Currently, we think CBDA is being converted to CBD once it is absorbed by the body through as yet unknown mechanisms. However, this means you can get grater benefits of both CBDA and CBD by just taking high amounts of CBDA formulations!
CBD levels are higher in the blood after ingestion of hemp oil with CBDA compared to hemp oil without CBDA3
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1) Pellesi, L., et al, “Pharmacokinetics and tolerability of oral cannabis preperations in patients with medication overuse headache (MOH) – a pilot study.” European Journal of Clinical Pharmacology, 2018, 74(11):1427:1436. PMID: 29980818
2) Szaflarski, P. J., et al, “Higher cannabidiol plasma levels are associated with better seizure response following treatment with a pharmaceutical grade cannabidiol.” Epilepsy & Behavior, 2019, 95:131-136. PMID: 31048098
3) Eichler, M., et al, “Heat exposure of Cannabis sativa extracts affects the pharmacokinetic and metabolic profile in healthy male subjects.” Planta Medicine, 2012 May;78(7). PMID: 22411724