CBDA Dose: What Should I Know?

CBDA Dose: What Should I Know?

  • On 2022-09-22

CBDA dose whats right for you

CBDA Dosage: A guide on how much CBDA to take


You are interested in using CBDA or CBD for anxiety relief or improve your mental well being, but what is the dosage you should take? A typical product recommendation for CBDA or CBD dosage ranges from 10mg to 100mg per day, but these are dependent on the individual.

Should the dosage for CBDA be different than CBD? Yes!

CBDA is absorbed by the body over 400% more than CBD.

Below is the NaturalDos guide to your daily dose of CBDA.

What is the right CBDA dose for me?

The amount of CBDA or CBD that works for you will vary depending on a number of factors:

  • The state of your endocannabinoid system
  • What condition you need help with
  • Concentration of the CBDA oil or CBD oil in the tincture, breath mint, gummy, or capsule
  • Body weight
  • Personal biochemistry

These are a lot of variables, and shows why finding the right CBDA dosage for you will rely on varying the dosage for your personal needs.

Tracking your dosage and noting the benefits on those days to see how you respond is recommended.

Where do you start when testing out if CBDA oil is right for you? NaturalDos offers a couple different doses depending on the product. We recommend that you start out with a single dose depending on what product you prefer.

  • If you bought a dropper, start with 50mg.
  • If you bought the breath mints, start with 20mg, 1 mint.
  • If you bought the gummies, start with 30mg, 1 gummy.

CBDA is the parent cannabinoid to CBD, and is what is found in the hemp plant. However, since it was hard to isolate for commercial purposes, there has not been as many studies on it as CBD oil. Most of the dosage studies assessing beneficial amounts are using CBD, so we have to use those for starting purposes.

Clinical studies testing the beneficial effects of CBD have used a wide variety of doses from 20mg per day up to 2000mg per day!

Examples of some clinical trials below with references at the bottom of the page:

  • Social Anxiety: Ingestion of 600mg CBD dose1
  • Nicotine addiction: Ingestion of 800mg CBD dose2
  • Opioid Addiction: Ingestion of 800mg CBD dose3
  • Seizure control: Ingestion of 25mg/kg to 50mg/kg of CBD. This converts to 1750mg – 3500mg CBD for a 150lb person.4

As you can see, sometimes it takes a significant amount of CBD to get a benefit. This would mean you would go through multiple bottles a week at these doses. At these doses, you should consult your physician since some medications may have interactions with CBD and can affect liver function.

This is what makes CBDA so powerful, it absorbs over 400% more than CBD, and also yields greater CBD blood levels than taking CBD by itself. You need much less of it to get a benefit.

Correlating CBD and CBDA dosage

Because CBDA has greater absorption than CBD, we need to calculate how much CBDA to take to reach a similar bioavailability as CBD.

Beware, lots of calculations below, you can skip to the results picture

In this study they found that average blood concentration of CBDA was 96.05 ng/mL with a dose of 8.82mg. CBD had a blood concentration of 4.39 ng/mL with a dose of 1.93. The ratio of dose to absorption for CBDA is 10.9 and 2.3 for CBD, which means that CBDA absorbs over 450% (4.78 ratio) more than CBD. Using this ratio we can roughly calculate how much CBDA you would need to take to get the same blood concentrations as CBD:


You only need 450% less CBDA than CBD to reach similar levels. Divide your normal CBD amount by 5 to get a rough estimate of the CBDA amount to take.

As you can see from the calculations above, significantly less CBDA oil is needed to reach similar blood concentrations as CBD oil. While everyone will absorb different amounts, the data was the average for the study population.

This is important because the typical doses studied in many clinical trials are very high, and thus cost prohibitive to consumers.

New CBDA hemp oil absorption study

A recent study assessing the absorption of multiple acidic cannabinoids from hemp oil in mice have found a much higher bioavailability than prior studies, over 1000% greater than CBD. However, we should note that the analysis we presented above is from humans, which is the gold standard, while animal studies are good at teasing out the possible mechanisms and potential dose ranges.

The data from this study found a couple may highlights:

  1. CBDA has over 1000% better absorption than CBD when taken as a full spectrum Oil.
  2. CBD appears to have better absorption as an isolate compared to full spectrum extract
  3.  All acidic cannabinoids have much greater absorption than their decarboxylated forms
  4. Only CBDA has greater absorption when taken in full spectrum extract, over 500% better!

These are exciting results, and highlight the need for further human studies at different doses and extracts.


How much is in a dropper?

NaturalDos tinctures come in 2 amounts, 500mg and 1000mg. Because our tinctures are more concentrated than most other tincture products, they come in two volumes, 5mL and 10mL. The concentration of both amounts is 100mg/mL and each have a graduated dropper. For a 50mg dose, use 0.5 mL and for a 100mg dose, use 1 mL. See below for reference:


How many doses will I get out of my tincture?

This will depend on the dose that is right for you. We have made an easy guide below to determine the tincture dosing for CBDA:



How to calculate dosage

Calculating dosage for tinctures can be complicated since many products are sold with different amounts of CBDA. Most manufacturers use a 30 mL bottle, but they may have different amounts of CBDA in their product, meaning 1 mL from one company does not have the same amount of CBDA as 1 mL from another.

How to calculate out the amount of CBDA per dose:

Amount of CBDA (500mg) / total volume of bottle (30mL) = amount of CBDA in 1 mL (17 mg)

A brief reference guide for how to dosage CBD and CBDA:



CBDA and CBD have many health benefits

There is a lot of information online about the many health benefits of CBDA and CBD. We wont cover all of them but people have reported benefits for some of the symptoms below.


The hemp plant contains many different cannabinoids, and in their natural state CBDA is the most abundant. While CBDA is not psychoactive, in other words it wont get you “high”, there are many benefits to cannabinoids that people have reported:

  • Anxiety and depression
  • Help with sleep and insomnia
  • Joint discomfort
  • Provides benefits for pain and inflammation

Whatever benefits you are looking for, it is important to find the right dosage for you before determining if hemp derived products can help.


Can I take too much CBDA or CBD?

As we found out earlier in the post, clinical studies typically use high doses of CBD to reach therapeutic outcomes with few side effects to participants.

While minimal side effects have been reported at lower concentrations, such as below 100 mg, it is important to consult your physician if you are on medications or have liver complications.


Choosing the right type of CBDA or CBD

Hemp cannabinoids like CBDA and CBD come in different types based on the manufacturing process. The 3 main types of product are:

Isolate: only 1 cannabinoid, typically CBD

Full Spectrum: contains CBD, THC, and other cannabinoids

Broad-Spectrum: contains CBD, no THC, and other cannabinoids

Natural Spectrum CBDA: contains all the natural cannabinoids found in the hemp flower such as CBDA, CBCA, CBDVA and other acidic cannabinoids.


How to take CBDA or CBD


CBDA products can come in other forms as well. Try some of these if you do not like taking tinctures:

  1. Gummies
  2. Capsules
  3. Breathe mints
  4. Flower
  5. Drinks
  6. Vape

While CBD vaping and flower are popular, we don’t usually recommend because the heated compounds in those products may have adverse health effects.

Take CBDA before you eat, or when you have not eaten in a couple hours. Recent research found that when you take CBDA or CBD before eating, then it is better absorbed by the body. It appears that ingesting CBDA on an empty stomach can double the concentration in the blood!


Consult your physician

While CBDA has minimal side effects, if you are on medication or have liver complications, talk to your healthcare provider, and see if they can recommend a CBDA dosage or CBD dosage. There may be drug-drug interactions with CBDA, even though only CBD has been studied specifically to address this question.



  1. Mateus M. Bergamaschi et al, “Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients”, Neuropsychopharmacology, 2011, May;36(6):1219-26. PMID: 21307846
  2. Chandni Hindocha et al, “Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal”, Addiction, 2018, May 1;113(9):1696-1705. PMID: 29714034
  3. Yasmin L. Hurd et al, “Cannabidiol for the reduction of cue-induced craving and anxiety in drug-abstinent individuals with heroin use disorder: A double-blind randomized placebo-controlled trial”, American Journal of Psychiatry, 2019, Nov 1;176(11):911-922. PMID: 31109198
  4. Elizabeth A. Thiele et al, “Long-term cannabidiol treatment for seizures in patients with tuberous sclerosis complex: An open-label extension trial”, Epilepsia, 2022, Feb;63(2):426-439. PMID: 34957550


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