CBDA for Nausea
- On November 21, 2022
CBDA for Nausea
The feeling of nausea can stop you in your tracks, especially if its nausea and vomiting.
Going out with friends? Maybe next time, I need to spend time in the bathroom just in case.
Anxious about a social event at work that leads to nauseas feelings? Better to avoid just in case.
Have you developed an anxiety to being in social situations whereby there is pressure to not be feeling sick or vomiting?
Nausea and vomiting can arise from environmental cues, something internal, or both. It can come on suddenly, without warning, and maybe you feel it in your throat making it hard to speak.
If this sounds like you, try CBDA now and take back your life!
- What is nausea
- Where to find the best CBDA
- Causes of nausea
- What is CBDA?
- How does CBDA affect nausea and vomiting
- How to take CBDA
- Safety and side effects
What is nausea
Nausea is defined as “the sensation of having to vomit or the urge to vomit”. Having nausea does not alway lead to vomiting, but it is certainly an early indicator that it could happen.
While nausea and vomiting are natural responses to most food poisonings, there are many psychological reasons people may be experiencing chronic nausea and vomiting, or just in some social environments that trigger this response.
Where to find the best CBDA
Cannabidiolic acid (CBDA) has been tested in multiple labs to help with nausea, but where can I get the best CBDA?
Natural Dos scientists have developed a new technology that unlocks the potential of the Natural Spectrum CBDA Oilfound in the hemp flower. All of our products are of the highest quality, and tested by certified 3rd part labs in the USA.
Try our flavorful Tropical Vegan CBDA Gummies. These gummies taste great and come with 30mg of CBDA plus all the minor acidic cannabinoids for the full entourage effect.
Enjoy the instant relief with our on the go CBDA tinctures. Our Natural Spectrum CBDA Tinctures come in Orange Zest, Mint, and Raw flavors, and are the most concentrated in the industry! In 5mL and 10mL vials, they easily fit in your pocket for whenever you need.
Get great breath with our refreshing CBDA Breath Mints! Pack a tin and enjoy the relief with fresh breath on the go.
Causes of nausea
Nausea and vomiting can come from many different places. Sometimes it is obvious, such as food poisoning, but sometimes it can be psychological in nature, such as anxiety.
What does the science and research say about nausea and vomiting? Below we have outlined some of the causes that can lead to nausea:
Anxiety can cause nausea, not everyone appreciates that the gut is home to the most nerve cells outside the brain. Hormones and neurotransmitters released by the nervous system during heightened states of anxiety cause disruptions in normal gut function leading to nausea and vomiting.
Anxiety is often associated with acute and anticipatory nausea, where anxiety around an upcoming event elicits nausea as a response. During states of anxiety, the body activates the flight or fight response, and this can lead to changes in cortisol and neurotransmitters that affect the gut.
Nausea and vomiting are commonly associated with irritable bowel syndrome (IBS), with up to 40% of women and 30% of men reported having nausea. Nausea symptoms can often be a response to gastroesophageal reflux disease, common for IBS patients.
For patients with IBS, anxiety around the disease itself may cause nausea, in a biopsychosocial feedback system. Unfortunately, psychosocial factors relating to the disease can themselves further exacerbate the underlying conditions, making it difficult to treat an already complex pathology.
Excessive alcohol consumption
The association of alcohol consumption with nausea and vomiting is well understood and is not an uncommon experience for many people. Alcohol consumption can also lead to anxiety the following day, which has been termed hangxiety.
Headaches with severe throbbing pain, sometimes with a pulsing sensation, on one side of the head are often termed migraines. Often, nausea and migraines are associated, and there seems to be a biological response in the brain circuitry underlying migraines that influences nausea and vomiting symptoms.
Surveys of patients with chronic migraines found that around 90% also had symptoms of nausea and vomiting.
One of the associated symptoms of COVID-19 infection is nausea, which was puzzling at first since it is a respiratory disease. However, the Sars-cov-2 virus has been found in fecal matter, and the gut epithelial cells have a substantial amount of the ACE2 (angiotensin converting enzyme 2) receptor on their cell surface. This is important since the ACE2 receptor is how the virus binds and enters the cell.
Food poisoning can be caused by ingestion of a number of different harmful pathogens. These include can include pathogenic bacteria, viruses, or parasites. Additionally, nausea and vomiting can be caused by toxins associated with these microorganisms.
These symptoms are usually acute, and can be treated by a medical professional if they do not resolve on their own.
Chemotherapy induced nausea and vomiting
Nausea and vomiting are a common side effect of many cancer treatments, such as chemotherapy and radiation. The onset of nausea can be different for individuals, such as acute or delayed after treatment. It can also take the form of anticipatory nausea, where patients which is a learned response from multiple treatments.
For cancer chemotherapy induced nausea and vomiting, cannabis has been widely tested for its anti nausea effects. Clinical trials, including this phase 2 THC:CBD combination, have found substantial benefits for chemotherapy patients.
In early pregnancy, morning sickness, nausea in the morning, is very common. While most common when waking up, it can linger throughout the day, and is usually gone by 24 weeks of pregnancy.
What is CBDA?
Cannabidiolic acid (CBDA) is the most predominant cannabinoid in the hemp flower. In fact, all cannabinoids in their natural state are in the “acid” form. The cannabis plant, whether hemp or marijuana, have over 100 different cannabinoids. In the hemp flower, CBDA is the most abundant cannabinoid, and in the marijuana flower, THCA is the most abundant.
During drying, extraction, and purification of the hemp flower, the acidic cannabinoids are converted to their non acidic forms. These are what is widely seen in hemp oil products, such as CBD, THC, CBG and sometimes THCV.
Do cannabinoids need to be decarboxylated to be active?
The idea that acid cannabinoids need to be decarboxylated with heat prior to use comes from the marijuana industry. Most marijuana products are designed to get you high, and here, THCA needs to be converted to THC to yield its euphoric properties. However, THCA on its own has a significant number of effects on the endocannabinoid system outside of creating a psychoactive effect.
CBDA and enhanced absorption
How well a compound works depends on how well it is absorbed by the body, this is called bioavailability.
Acidic cannabinoids, such as CBDA, have MUCH higher absorption than their decarboxylated forms. In fact, CBDA is over 450% better absorbed than CBD, meaning a 50mg dose of CBDA is about the same as a 250mg dose of CBD, and it may even be higher.
How does CBDA affect nausea and vomiting
The effects of CBDA on nausea is well studied in preclinical trials, and shows substantial promise for treatment.
Research on CBDA and nausea and vomiting
This study comparing CBD to CBDA found that cannabidiolic acid prevents vomiting using lithium chloride (licl) induced conditioned gaping in rats and shrews. They also used a classic model of cisplatin induced emesis (vomiting) to evaluate the effects of CBDA and the mechanisms of action.
They found that the primary action of cannabidiolic acid that attenuates vomiting was through activation of the 5HT1A receptor. The 5HT1A receptor is involved with regulating serotonin activity, and is a target associated with SSRIs (selective serotonin reuptake inhibitor). This receptor was found to be critical for chemotherapy induced nausea (cisplatin) in neurologically normal rats since they used a known inhibitor to prevent CBDA binding to the receptor.
Anticipatory nausea is a common condition in chemotherapy patients, where patients receiving cancer chemotherapy have nausea and vomiting symptoms prior to a treatment. This is termed learned behavior, and occurs in up to 30% of patients receiving cancer chemotherapy.
Anticipatory nausea model – lithium chloride: LiCl induced conditioned gaping in rats was assessed with and without CBDA administration. The results found that CBDA alone, and in combination with THC was able to prevent anticipatory nausea, and that the CB1 and 5HT1A receptors played a critical role in regulating the symptoms.
The single dose anti nausea effects of cannabidiolic acid are repeated in multiple preclinical studies, which is a good indicator that it has significant potential. However, can repeated use of CBDA lead to tolerance, and thus have no effect on acute nausea symptoms?
To test the possibility that repeat dosing leads to tolerance, and rat model of LiCl induced conditioned gaping was used. Repeated administration of CBDA up to 7 days prior to nausea and vomiting induced by LiCl did not lessen the effects compared to a single dose of CBDA. This study suggests that cannabidiolic acid prevents vomiting and nausea even after multiple treatments, and thus did not see any indication of tolerance buildup.
The main treatment for anticipatory nausea in chemotherapy patients is benzodiazepine anxiolytics. However, these have significant side effects related to addiction, tolerance, and locomotor effects. Since CBDA is not psychoactive, it is not considered to be addictive.
To see if CBDA has effects on the neuromotor system responsible for physical movement, CBDA was given to male rats. The researchers found no difference in neuromotor function, but a significant reduction in scores on anxiety tests.
There are many preclinical studies on CBDA showing anti emetic efficacy. While nausea and vomiting are often associated with cancer patients, things like anxiety, morning and motion sickness, among others, can yield similar symptoms that could benefit from CBDA.
More clinical trials studying CBDA and its anti nausea effects are needed. The use of CBDA for nausea has not been approved by the FDA.
How to take CBDA
If you decide to try CBDA for nausea, Natural Dos has tinctures, gummies, and breath mints. If swallowing is difficult, tinctures and mints are ideal since they are absorbed best if left under the tongue.
If using the CBDA tincture, take 0.5mL (half a dropper, 50mg CBDA), and place under the tongue for at least a minute. Sublingual administration (under the tongue) is used for its high absorption properties.
Natural Dos breath mints melt in your mouth, and are also well absorbed if taken under the tongue. Each mint has 20mg of CBDA, find which amount works best for you!
There is no right dose of CBDA for everyone, so we recommend you start a dose with 20-50mg and determine from there what works for you.
Safety and side effects
Cannabinoids from hemp are well tolerated, with minimal significant side effects. Most side effects users report are:
- Dry mouth
- Low blood pressure
From a safety perspective, there have been no clinical trials assessing CBDA. There is evidence that CBD is metabolized through the Cyp450 pathway in the liver from work done on the prescription CBD drug Epidiolex. These clinical trials found that CBD in high doses, 1000mg per day and over, could interact with other medications leading to elevated liver enzymes.
Care should be taken if you are on multiple medications and taking higher doses of CBDA or CBD. Talk to your health care provider if you have a history of liver complications.
Because acute and anticipatory nausea can come from many different sources, it may mean that there is no one treatment for all causes. Preclinical studies and many users report that CBDA oil helped with anxiety, so it may also help with those who have anxiety related nausea and vomiting.
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