CBDA vs CBD – Understand the Difference and Benefits

New research is finding that CBDA oil (cannabidiolic acid) has significant health benefits for the endocannabinoid system, and also has anti-inflammatory properties not seen from CBD oil (cannabidiol). With new CBDA products coming on the market, and recent publications showing CBDA can help with sleep, anxiety, and inflammation, people are wondering about the benefits of CBDA vs CBD.

One of the main health benefits of CBDA is its very high absorption compared to CBD, allowing a much smaller amount to be used for medicinal benefits.

CBDA and CBD have some similar benefits, as shown by researchers assessing effects on cellular function, but they both some unique properties as well due to their structural differences.

What are the benefits of CBDA vs CBD?

Many studies have reported on the benefits and effects of CBDA and CBD:

• Problems falling asleep
• Social anxiety
• Elevated stress
• Nausea
• Joint discomfort
• Headaches
• Seizure control
• Metabolism

CBD has been widely tested, in part due to its ease of extraction and from early studies showing its interactions with the endocannabinoid system through the CB2 receptor. CBDA has also been shown to interact with the CB2 receptor, although at a lower affinity than other cannabinoids like THC and CBD.

CBDA is a more recent compound to be studied in the hemp oil research space, but is gaining traction as an important modulator of the endocannabinoid system. The difference between cbda oil and cbd oil is under active research, but may hinge a lot on the absorption properties.

Absorption

One of the main benefits of CBDA vs CBD is the enhanced absorption of CBDA compared to the decarboxylated CBD form. Clinical trials evaluating the blood levels of CBDA vs CBD found that it had over 450% more absorption when taken orally.

Anti inflammation

New research is finding that CBDA may also have significant anti-inflammatory properties related to its ability to decrease COX-2 activity. COX-2 (cyclooxygenase 2) is a critical enzyme involved in driving inflammatory states. This enzyme is a common target for anti inflammatory drugs NSAIDS (nonsteroidal anti inflammatory drugs), commonly know as Ibuprofen.

Nausea

Nausea is another symptom that has been studied as a significant potential target for the use of CBDA. There are a number of animal studies showing that CBDA is beneficial in decreasing symptoms of nausea. Anti nausea and vomiting appear to be a potent target for CBDA through the body’s endocannabinoid system, but has not been approved by the food and drug administration for this condition.

Metabolism

There are a number of studies performed in vitro showing that CBDA is able to reduce breast cancer growth in MBA-231 cell lines. While this was found to involve COX-2 regulation, researchers also found that CBDA repressed PPAR-beta/delta receptors involved in metabolism and that this was critical in regulating the cancer growth in cells. With the recognition that CBDA can influence critical metabolism enzymes, other researchers have tested its affect on obesity. Pre-clinical trials in vivo are finding that CBDA induces weight loss and lead to fat reduction in a mouse model of obesity.

Anxiety

The effects of CBDA and anxiety are just starting to be assessed in pre-clinical trials to see if it has similar actions as CBD. These early studies in rats show that it can decrease symptoms of anxiety at 10-fold lower concentrations that what was needed from CBD. The mechanism of actions appear to be from CBDA interactions with the 5HT1A receptor, a class of serotonin receptors involved in brain function. These are classic targets of SSRIs (selective serotonin receptor inhibitors), which are used to affect the nervous system in patients with depression.

 

CBD vs CBDA: how to properly dose

The right dose is different for everyone depending on their size, unique body chemistry, and what benefit they are trying to get out of their hemp oil. Because there are limited clinical studies on CBDA benefits, we have to use the clinical studies from CBD as an approximate baseline.

Many CBD studies testing efficacy for sleep, anxiety, depression, pain, and nausea use what would be considered higher doses. These can range from 50mg up to 600mg per day. Most of the studies that show significant benefit are in the 200mg to 600mg range. In fact, the only FDA approved treatment for CBD is refractory epilepsy, and there children and adults average over 1000mg of CBD per day.

For CBDA we suggest that users start somewhere in the 20mg to 50mg range, and determine what feels best for them. Since this has not been evaluated by the FDA, there is no set amount for daily use.

Since CBDA has around 450% more absorption than CBD, a 50mg dose would be similar to a CBD dose of 250mg. This is also much more cost effective for customers since most CBD products would only have a couple days worth of doses in a bottle.

 

What are acidic cannabinoids?

CBDA (cannabidiolic acid) is an acidic cannabinoid, a class of compounds found in the hemp plant, with the highest concentration in the flower. Acidic cannabinoids are the natural state of cannabinoids found in hemp, and are derived from the mother cannabinoid CBGA. The raw form of cannabis plants extract contain high amounts of cbda and thca, although thca is often much lower in concentration (2% vs 40%). However, further purification is often needed to remove unwanted plant material to reach a reasonable flavor profile and dose of cbda for tinctures or other edible products.

An acidic cannabinoid is defined by the presence of a certain type of molecular structure termed a carboxylic acid (-COOH). This structure can be lost during purification and extraction of hemp oil, which, for example, converts CBDA to CBD, a process termed “decarboxylation”.

There are over 100 different acidic cannabinoids, such as CBDA, CBGA, and THCA, that are naturally produced in the cannabis plant, and they all can have varying benefits depending on the amount and combination used. These major cannabinoid precursor compounds, typically referred to since they come before decarboxylation, are part of the Natural Spectrum CBDA oil produced by Natural Dos, and would be termed full spectrum by the broader market since they contain all the cannabinoids.

 

How is CBDA different from CBD?

CBDA is different from CBD in that it has a carboxylic acid that is not found on the CBD molecule. Structurally they are very similar to each other, and in the plant only convert non-enzymatically. See the diagram below for reference:

The hemp plant, and all Cannabis Sativa strains contain many different cannabinoid types, but naturally they are all in the acidic form.

CBDA can break down (decarboxylate) into CBD if left in the heat or exposed to sunlight for extended periods of time. Most manufacturers recommend that you place CBDA products away from sun exposure and at room temperature.

When it comes to product formulation, CBDA has a strong peppery taste that CBD lacks. This is also why a lot of CBDA tinctures are very dilute, with some sellers only using edibles that hide the CBDA taste.

 The absorption studies show that CBDA is better than cbd for uptake purposes. However, the effects of cbd and cbda oil may differ in how well they interact with the CB1 and CB2 receptors. It should be noted that the ability of compounds to provide health benefits like CBD and THC are also dependent on how much gets into the blood. Thus, affinity for a single target should be balanced by the amount taken in by the body.

 

CBDA vs CBD for pain

A lot of the new pre-clinical research is finding that CBDA has potent anti pain properties due to a couple unique factors.

The first is that CBDA can directly inhibit COX2 (cyclooxygenase 2), a potent pro-inflammatory enzyme that is also the target for many NSAIDs like aspirin and ibuprofen. It also appears to decrease the production of COX2 as well, which can limit the propagation of inflammatory signaling.

It is well known that reducing inflammation is one of the best way to decrease pain in problem areas like joints or peripheral nerves.

For direct pain sensation, there is now evidence that CBDA can inhibit pain sensation, and this appears to be through the TRPV1 channels (transient receptor potential cation channel subfamily V member 1). These are known targets for pain sensitivity and have been closely studied in the capsaicin field.

CBD has also been studied for its pain relief problems, but has not translated well due to its poor absorption. Similar to anxiety relief the doses required are high and usually cost prohibitive.

New purification methods for CBDA

Initial extraction of cannabinoid oil from the hemp flower results in high concentrations of CBDA, CBGA, and CBCA depending on the strain. This can be seen in live rosin extracts which use compression to “squeeze” out the acidic cannabinoids from the flower. However, most extractions, such as ethanol and CO2 based, will have CBDA in their crude extract which gets converted to CBD during purification or solvent remediation.

 

Crude extracts contain many different organic compounds and remnants from the hemp plant, which means it needs to be further purified before product use. Conventional purification uses short-path distillation, a method involving heating the crude under a vacuum to boil off only the wanted cannabinoids and some terpenes. However, this process decarboxylates the acidic cannabinoids, converting CBDA to CBD or CBGA to CBG.

Only recently has some of the benefits of acidic cannabinoids been discovered, and this has led to renewed interest in finding better ways to isolate cannabinoids without destroying them. Natural Dos uses a water purification technology developed in house over the last couple years which produces a Natural Spectrum CBDA Hemp Oil. This contains all the acidic cannabinoids that a hemp flower has in it, such as CBDA, CBCA, THCA, CBDVA and others.

Full spectrum CBD oil is thought to provide superior benefits to single cannabinoid products (known as isolates). This is referred to as the “entourage effect”, where the combination of multiple cannabinoids have a greater benefits than in isolation. A recent study out of the University of Sydney found that cannabis plant oil had enhanced CBDA absorption when taken in combination with other cannabinoids. This CBDA enhanced absorption was over 14-times higher when taken in combination than as an isolate!

 

Where to buy high quality CBD oil and CBDA oil?

To find the best CBDA oil, a reputable manufacturer is critical, but it is difficult to determine who to trust. All quality CBDA products should have a certificate of analysis (CoA). Whether the product is listed as raw hemp, raw cannabis, or CBDA oil, the CoA should list 5 basic parameters:

• Potency – how much of the cannabinoids are in the product
• Heavy metals – the cannabis plant can soak up heavy metals from the ground
• Solvents – various solvents are used during the extraction and purification stage
• Pesticides – while pesticides are not legally allowed to be used for hemp cultivation, they can be left over in the soil
• Microbial – whenever a food product is made, its important that any potentially harmful bacteria or fungus is tested for
• Third party certified – did the company send their final product to get tested at a reputable testing facility? A good testing lab will be ISO 17025 certified or have a similar certification from an accreditation agency.

If you are not familiar with how to read a CoA, check out our cannabinoid CoA guide on interpreting the results.

Natural Spectrum CBDA products from Natural Dos all have the full spectrum of acidic cannabinoids found in cannabis plants, providing the highest absorption benefits. Try out CBDA Gummies if you are a fan or the always famous CBDA Tinctures as well.

All products are 3rd party tested for potency and purity by an ISO 17025 certified laboratory with over a decade in experience (SC Labs).

 

Is CBDA legal?

Legally, CBDA is regarded in a similar fashion as the cannabinoid CBD. The 2018 Farm Bill legalized the production of hemp, which is the primary cannabis plant that it comes from. After legislation, CBD products gained prominence as a unique nutraceutical across the country. Only states that have a regulated hemp license and oversight program are allowed to operate hemp farming and processing facilities. Because CBD and CBDA does not intoxicate people, they can be used for nutraceutical purposes in most states. CBD and CBDA products can contain THC or THCA (full spectrum), or can have the THC removed (broad spectrum). However, if they do contain THC, they are legally not allowed to have over 0.3% THC by dry weight.

 

Summary

Because of the involvement of the endocannabinoid system in most parts of the body, hemp derived cannabinoids can have profound effects for many different purposes. While CBD has been well studied for a wide range of ailments, CBDA may be significantly more effective due to its unique absorptive properties and anti-inflammatory actions.

It is important to note that people with preexisting conditions should consult with their physician to determine if there are any potential drug-drug interactions. Some data from epilepsy studies indicate potential liver complications in those patients taking high doses of CBD along with other drugs. CBDA has not been approved by the food and drug administration for treatment, and CBD has only been approved for some epilepsy conditions under the brand name Epidiolex.

Let us know if you have any questions or want to see a specific topic covered on our website.

–Team Dos