CBDA for Nausea – Exploring the Potential Benefits

Feel that awful, queasy discomfort we’ve all had at some point? Yeah, nausea. It’s definitely no fun, and sadly it actually affects millions of people around the world for all sorts of reasons—illness, anxiety, and even cancer treatments.

But hey, there’s good news! As we quest for ways to make it better, we’ve come across some pretty cool natural remedies.

One of them is this natural compound called CBDA (cannabidiolic acid) from the cannabis plant. While the cannabis plant has been used for a long time to treat nausea and vomiting in chemotherapy patients, the emergence of new CBDA purification technology is changing the field.

So let’s chat about nausea, what causes it, and how CBDA might help us out. We’ll dive into the world of this lesser-known gem, and see if it can give us a break from that pesky nausea. Ready to learn? Let’s go!

Article Highlight:

• Cannabidiolic acid (CBDA) is a non-psychoactive compound found in raw hemp. Among other acidic cannabinoids, CBDA has been getting some buzz for its potential in easing nausea.
• So, CBDA works through multiple interactions, including our body’s endocannabinoid system.
• Additionally, CBDA activates serotonin receptors, which are found to be important in controlling feelings of nausea.
• CBDA comes in different forms, like oils, capsules, and even edibles. You’ll usually find dosages ranging from 10mg to 50mg per serving.
• Before you jump on the CBDA bandwagon, it’s important to know that more research and clinical trials are needed to figure out the best dosage, safety, and how effective it really is for humans.

Jump to:

• How CBDA works for nausea
• Benefits of CBDA for nausea and vomiting
• Forms of CBDA for nausea treatment
• Other health benefits of CBDA
• Potential side effects of CBDA
• Conclusion

How CBDA Works for Nausea

Did you know that cannabidiolic acid (CBDA) is the most abundant acidic cannabinoid found in the cannabis plant? But its also just one of over 100 different cannabinoids in the flower.

When it’s exposed to heat, such as during conventional purification processes, the cannabinoid profile of CBDA converts into CBD (cannabidiol).

So, you can think of CBDA as a kind of CBD acidic precursor. Preliminary research has shown that CBDA might help reduce both acute and anticipatory nausea, as well as chemotherapy induced nausea. CBDA works in the body the same way CBD does, at least in some aspects, such as interactions with the endocannabinoid system (ECS) throughout our bodies.

The ECS is this complex cell-signaling system that plays a huge role in keeping our bodies balanced. It’s made up of three main parts:

1. Endocannabinoids (these are compounds our body makes that are similar to the ones in cannabis)
2. Receptors (mostly CB1 and CB2)
3. Enzymes that break down endocannabinoids

Our ECS is involved in a whole bunch of stuff we do every day, like eating, feeling pain, and even affecting immune system. CBDA teams up with the ECS to help reduce nausea and vomiting in a few different ways:

• Turning on serotonin receptors: CBDA really likes to bind with the 5-HT1A serotonin receptors, which can help control nausea and vomiting. Studies have shown that when CBDA activates these receptors, it can reduce anticipatory nausea and other related symptoms, like nausea-induced behaviour.
• Indirectly modulating CB1 receptors: Unlike THC, CBDA doesn’t bind directly to CB1 receptors very well, but has more interactions with CB2.
• Boosting anandamide levels: Anandamide is one of those endocannabinoids we mentioned earlier, and it interacts with CB1 receptors to possibly help control nausea. CBDA might increase anandamide levels by stopping the COX2 enzyme that breaks it down, which in turn could offer some anti-nausea benefits.

Scientific Research Supporting CBDA’s Effectiveness for Nausea and Vomiting

Now, let’s dive into the scientific research that supports the effectiveness of CBDA for nausea and vomiting relief!

First up, a study published in the British Journal of Pharmacology compared CBDA and CBD for nausea relief. They tested both compounds on animal models and found that CBDA was actually more effective at reducing nausea induced behavior than CBD. Pretty interesting, huh?

Another study, also published in the British Journal of Pharmacology, investigated the role of anandamide (an endocannabinoid) in CBDA’s anti-nausea effects. The researchers found that CBDA can increase anandamide levels in the brain, which could be one way it helps reduce nausea. Additionally, CBDA has also ben found to be extremely beneficial to cancer patient undergoing chemotherapy treatment and experiencing nausea and vomiting as side effect.

And, a current research published in Phytotherapy Research focused on the oral and serum bioavailability of CBDAcompared to CBD and other cannabinoids in human subjects. CBDA was found to be 1000% better absorbed than CBD, and was detected in both the blood and saliva.

The team discovered that CBDA is actually more bioavailable than CBD and other acidic cannabinoids, making it a better option for oral administration to treat nausea and vomiting.

Of course, it’s important to keep in mind that most of these nausea studies were done on animals, so we still need more research and clinical trials with humans to fully understand how effective and safe CBDA is for treating nausea.

 

Benefits of CBDA for nausea and vomiting

You know what’s awesome about CBDA? It has some major advantages over other nausea medications, thanks to its unique way of working with the ECS, serotonin receptors, fewer side effects, and all-natural goodness.

When it comes to traditional nausea meds like anticholinergics and serotonin antagonists, they can sometimes cause side effects and not always give you the relief you’re looking for.

But CBDA is different! CBDA interacts with specific receptors, which means it targets nausea and its symptoms more precisely.

Another great thing about CBDA is that it has a lower risk of side effects. Preclinical studies have shown that it’s well-tolerated with minimal adverse events, making it a safer and comfier option for anyone seeking nausea relief – especially if you’re sensitive to the side effects of conventional meds.

And let’s not forget that CBDA is a natural compound found in raw cannabis plants, so it’s got a leg up the standard treatment. If you’re into natural and organic remedies, CBDA might be right up your alley. It’s super helpful for cancer patients dealing with chemotherapy-induced nausea who want a natural solution. Plus, since CBDA has no psychoactive effects (meaning it won’t get you “high” like THC), it’s a fantastic choice for those who want the potential health benefits of cannabis without the mind-altering effects.

Forms of CBDA for Nausea Treatment

If you’re looking for ways to treat nausea with CBDA, you’ve got plenty of options. Let us tell you about some common CBDA products and how to use them:

CBDA Tincture: This popular and easy-to-use option is super convenient. Just place the oil under your tongue, and adjust the dosage based on how nauseous you feel. Start with 20mg to 50mg of CBDA per day and slowly increase if needed.

CBDA Capsules: If you like knowing exactly how much you’re taking, CBDA capsules are perfect for you. Capsules range from 20mg to 100mg each, so start low and gradually bump up the dose if necessary.

CBDA Gummies: Love a tasty treat? Gummies or candies infused with CBDA are both delicious and discreet. Just keep in mind that the dosage varies depending on the edible.

Figuring out the best CBDA product for you depends on your preferences, how severe your nausea is, and any medical conditions you have. For example, if you have intense nausea, oil or capsules might be your go-to since they offer higher dosages. But if you only have mild nausea, edibles could be just the ticket.

 

Other Health Benefits of CBDA

Besides being great at reducing anticipatory nausea and vomiting, CBDA has some other pretty cool therapeutic potential benefits. Let’s chat about some of these possible perks and the research behind them:

Anti inflammation properties: CBDA for inflammation has been a hot topic, and its anti inflammatory properties may ease symptoms in conditions like arthritis, joint pain, and even headaches. A research team found that CBDA reduced inflammation by putting the brakes on the COX-2 enzyme, which plays a big role in inflammation and pain. Another study even found that CBDA could be a powerful alternative to many nonsteroidal anti-inflammatory drugs.

Pain relief: Got chronic pain, neuropathic pain, or migraines? CBDA’s analgesic properties might be just the ticket. There are now multiple preclinical studies showing that many of the targets involved make CBDA for pain management a strong candidate in many future studies.

CBDA and Anxiety and stress: CBDA could lend a hand in easing anxiety and stress symptoms. A study in the journal Psychopharmacology discovered that CBDA might have anxiolytic-like effects, reducing anxiety-induced behaviors in animal models. Plus, its potential impact on serotonin levels could also contribute to its antidepressant effects.

Epilepsy: CBDA has been shown to have anticonvulsant properties in preclinical trials, making it a potential treatment option for epilepsy.

 

Potential Side Effects of CBDA

So you’re thinking about trying CBDA, right? It’s generally seen as safe to use, but like with any supplement or medication, there might be some CBDA side effects. Here’s what you might experience:

1. Dry mouth: CBDA could make your mouth feel dry by reducing saliva production.
2. Dizziness: Some folks might feel a bit dizzy or lightheaded after taking CBDA.
3. Appetite changes: CBDA might make you feel hungrier or less hungry than usual.
4. Fatigue: You could feel more tired or sleepy because of CBDA.

Now, if you’re using CBDA to help with nausea, it’s super important to be safe and make sure it works effectively:

• First, chat with a healthcare professional to figure out the best dosage and form for you.
• Start with a small dose and increase it gradually if needed.
• Hold off on driving or using heavy machinery while on CBDA, since it might make you drowsy or dizzy.
• Be careful when mixing CBDA with other meds or supplements, as it could interact with them.
• And if you have any severe or lasting side effects after taking CBDA, like really bad allergic reactions, trouble breathing, or chest pain, go see a doctor right away.

 

Conclusion

So, what we’re seeing is that the CBDA shows promising results in alleviating nausea, thanks to its interaction with the endocannabinoid and serotonin system . It works in a few different ways, like activating serotonin receptors and boosting anandamide levels. Even though we’re still learning about how effective CBDA is for nausea, the studies we’ve got so far are pretty exciting!

But hey, before you go and start using the acidic form of CBD for your nausea, it’s super important to chat with a healthcare professional. They’ll help you figure out the right dosage, form, and safety stuff to make sure you get the best results. With their expert advice, CBDA could be a game-changer in your battle against nausea and in boosting your overall well-being.

 

–Team Dos