Categories: CBDA Basics

CBDA Dosage: What is the Average Dose for CBDA?

If you considering using CBDA for anxiety relief or mental wellbeing, finding the proper CBDA dosage is paramount. If you don’t take a high enough dose you won’t attain the benefits that drew you to this powerful little cannabinoid in the first place.

Even though you won’t have to worry about an overdose or unpleasant effects from too much CBDA since it’s not psychoactive, you still don’t want to take more than necessary. This is not only wasteful but can contribute to a higher tolerance, meaning you have to take more and more over time.

Finding the right CBDA dose can be confusing and stressful, but don’t worry! Natural Dos has got you covered with this guide. A typical product recommendation for CBDA or CBD dosage ranges from 10mg to 100mg per day, but these are dependent on the individual.

As your trusted source for all things CBDA, you can count on Natural Dose for not just helpful tips and advice but also the most potent, pure CBDA products for sale online. Order yours now and discover the right dosage below!

Article Highlights

CBD is not not water soluble, and thus has low absorption. Most clinical studies end up using high doses between 200mg to 2000mg
Acidic cannabinoids, like CBDA, are water soluble and have much greater absorption, leading to superior benefits over their neutral form
New studies have now found that CBDA can have between 450% to 1000% better absorption than CBD
The ability of a compound to have an effect is largely determined by how well it is absorbed.

Article Highlights

CBD is not not water soluble, and thus has low absorption. Most clinical studies end up using high doses between 200mg to 2000mg
Acidic cannabinoids, like CBDA, are water soluble and have much greater absorption, leading to superior benefits over their neutral form
New studies have now found that CBDA can have between 450% to 1000% better absorption than CBD
The ability of a compound to have an effect is largely determined by how well it is absorbed.

What is CBDA oil?

First things first, what is CBDA? Also known as cannabidiolic acid, it is the most abundant cannabinoid in the hemp plant, and is the precursor to CBD oil production.

After extraction of the cannabis plants (the hemp species), the resulting crude extract is purified using a heating process called distillation.

Distillation is the conventional purification method, and it converts all the natural acidic cannabinoids, like CBDA, CBCA, CBGA (cannabigerolic acid) and others, into their neutral form. These include CBD, CBC, and CBG among others. Learn more about CBDA vs CBG in our blog.

With the proprietary purification method developed by Natural Dos, hemp extract is purified into CBDA oils that contain all the minor acidic cannabinoids. This new type of CBDA oil is termed Natural Spectrum CBDA oil, and is somewhat similar to the more common full-spectrum CBD oils.

Unique CBDA benefits

So, what is CBDA good for? With the enhanced absorption of acidic cannabinoids, the CBDA dose that the human body needs will be different than the CBD dose.

In addition to superior absorption, CBDA also has some unique properties found in many preliminary studies:

Anti inflammatory properties: CBDA was found to be a direct inhibitor of COX2 (cyclooxyrgenase 2), which is a critical enzyme that enhances inflammation. Not only can CBDA inhibit the enzyme activity, it has also been shown to decrease its production.
Anxiety disorders: Anxiety and stress are closely related, and like CBD oil, CBDA can also interact with the serotonin and endocannabinoid system receptors. Multiple pre clinical studies show substantial benefits using CBDA oils, which appear to work through these critical systems.
Joint pain: A common cause of pain, especially in joints, is excessive inflammation that can lead to activation of the pain receptors. In addition to impacting inflammation directly, CBDA has been found to inhibit pain signaling by blocking the TRPV1 channel which propagates pain signaling in the peripheral nerves.

Overall, the potential treatment options of CBDA oils are wide depending on the animal studies you look at. We think this new evolution in the CBD space has the potential to unlock the maximum support that the hemp flower offers.

CBDA Dosage: What is the Average Dose for CBDA Users?

With a better understanding of the benefits of CBDA, you’re likely eager to experience its effects firsthand. So, what CBDA dose should you take? We’ll look at factors influencing ideal CBDA dosage along with guidelines for specific use cases and product types below.

Factors Influencing Your Ideal CBDA Dose

So, what is the average dose for CBDA users? There is no one-size-fits-all answer to CBD oil dosage. The amount of CBDA or CBD that works for you will vary depending on a number of factors:

The state of your endocannabinoid system
What condition you need help with
Concentration of the CBDA oil or CBD oil in the tincture, breath mint, gummy, or capsule
Body weight
Personal biochemistry

There are a lot of variables and this shows why finding the right CBDA dosage for you will rely on varying the dosage for your personal needs.

Tracking your dosage and noting the benefits on those days to see how you respond is recommended. That being said, let’s look at the average CBDA oil dosage based on the consumption method in question.

CBDA Dose Guidelines Across Consumption Methods

Where do you start when testing out if CBDA oil dose is right for you? Natural Dos offers a couple different CBDA Tincture doses depending on the product. We recommend that you start out with a single dose depending on what product you prefer.

If you bought a CBDA tinctures, start with 50mg.
If you bought the CBDA breath mints, start with 20mg, 1 mint.
If you bought the CBDA gummies, start with 30mg, 1 gummy.

Now, remember that these are just general guidelines. We encourage you to start small and titrate to find the minimum effective dose and work with that. However, we’ll look at some CBDA medical uses and dosage guidelines below.

CBDA Medical Uses and Dosage Guidelines

CBDA is the parent cannabinoid to CBD, and is natural form found in the hemp plant. However, since it was hard to isolate for commercial purposes, there has not been as many studies on it as CBD oil. Most of the dosage studies assessing beneficial amounts are using CBD, so we have to use those for starting purposes.

Clinical studies testing the beneficial effects of CBD have used a wide variety of doses from 20mg per day up to 2000mg per day!

Examples of some clinical trials below with references at the bottom of the page:

Social Anxiety: Ingestion of 600mg CBD dose1
Nicotine addiction: Ingestion of 800mg CBD dose2
Opioid Addiction: Ingestion of 800mg CBD dose3
Seizure control: Ingestion of 25mg/kg to 50mg/kg of CBD. This converts to 1750mg – 3500mg CBD for a 150lb person.4

As you can see, sometimes it takes a significant amount of CBD to get a benefit. This would mean you would go through multiple bottles a week at these doses. At these doses, you should consult your physician since some medications may have interactions with CBD and can affect liver function.

This is what makes CBDA so powerful, it absorbs over 450% more than CBD, and also yields greater CBD blood levels than taking CBD by itself. You need much less of it to get a benefit.

Learn more about using CBDA for sleep, CBDA for nausea, CBDA for depression, CBDA for weight loss, and more in our blog.

Correlating CBD and CBDA dosage

Because CBDA has greater absorption than CBD, we need to calculate how much CBDA to take to reach a similar bioavailability as CBD.

Beware, lots of calculations below, you can skip to the results picture

In this study they found that average blood concentration of CBDA was 96.05 ng/mL with a dose of 8.82mg. CBD had a blood concentration of 4.39 ng/mL with a dose of 1.93.

The ratio of dose to absorption for CBDA is 10.9 and 2.3 for CBD, which means that CBDA absorbs over 450% (4.78 ratio) more than CBD.

Using this ratio we can roughly calculate how much CBDA you would need to take to get the same blood concentrations as CBD:

You only need 450% less CBDA than CBD to reach similar levels. Divide your normal CBD amount by 5 to get a rough estimate of the CBDA amount to take.

As you can see from the calculations above, significantly less CBDA oil is needed to reach similar blood concentrations as CBD oil. While everyone will absorb different amounts, the data was the average for the study population.

This is important because the typical doses studied in many clinical trials are very high, and thus cost prohibitive to consumers.

How much is in a dropper?

NaturalDos tinctures come in 2 amounts, 500mg and 1000mg. Because our tinctures are more concentrated than most other tincture products, they come in two volumes, 5mL and 10mL.

The concentration of both amounts is 100mg/mL and each have a graduated dropper. For a 50mg dose, use 0.5 mL and for a 100mg dose, use 1 mL. See below for reference:

How many CBDA doses will I get out of my tincture?

This will depend on the dose that is right for you. We have made an easy guide below to determine the tincture dosing for CBDA:

More Advice on How to Calculate CBDA Dosage

Calculating dosage for tinctures can be complicated since many products are sold with different amounts of CBDA. Most manufacturers use a 30 mL bottle, but they may have different amounts of CBDA in their product, meaning 1 mL from one company does not have the same amount of CBDA as 1 mL from another.

How to calculate out the amount of CBDA per dose:

Amount of CBDA (500mg) / total volume of bottle (30mL) = amount of CBDA in 1 mL (17 mg)

A brief reference guide for how to dosage CBD and CBDA:

Can I take too much CBDA or CBD?

As we found out earlier in the post, clinical studies typically use high doses of CBD to reach therapeutic outcomes with few side effects to participants.

While minimal side effects have been reported at lower concentrations, such as below 100 mg, it is important to consult your physician if you are on medications or have liver complications.

Choosing the right type of CBD or CBDA oils

Hemp cannabinoids like CBDA and CBD come in different types based on the manufacturing process. The 3 main types of product are:

Isolate: only 1 cannabinoid, typically CBD
Full Spectrum: contains CBD, THC, and other cannabinoids
Broad-Spectrum: contains CBD, no THC, and other cannabinoids
Natural Spectrum CBDA: contains all the natural cannabinoids found in the hemp flower such as CBDA, CBCA, CBDVA and other acidic cannabinoids.

We typically recommend a product that contains all the cannabinoids from the hemp plant for maximum benefits. When all the acidic cannabinoids are present, you get improved CBDA affects on the endocannabinoid and other systems that it targets.

How to take CBDA or CBD

CBDA products can come in other forms as well. Try some of these if you do not like taking tinctures:

While CBD vaping and flower are popular, we don’t usually recommend because the heated compounds in those products may have adverse health effects.

Take CBDA before you eat, or when you have not eaten in a couple hours. Recent research found that when you take CBDA or CBD before eating, then it is better absorbed by the body. It appears that ingesting CBDA on an empty stomach can double the concentration in the blood!

Consult your physician

If you are on medication or have liver complications, talk to your healthcare provider, and see if they can recommend a CBDA dosage or CBD dosage. There may be drug-drug interactions with CBDA, even though only CBD has been studied specifically to address this question.

Wrapping Up Our CBDA Dosage Guide

There you have it – our complete CBDA oil dosage guide. We hope you have a clear understanding of the ideal CBDA dose for you based on the specific product you’re taking and what you are taking it for.

Remember, there are a multitude of factors influencing the right dose for you. When in doubt, reach out – either to us here at Natural Dos or a physician specializing in cannabis as medicine.

Want to learn more about the fascinating world of CBDA? Our blog has helpful resources on topics like how to decarboxylate CBDA, CBDA side effects, best CBDA oil, does CBDA get you high, how does CBDA make you feel, CBDA absorption, and more.

At this point, though, it’s time for you to take what you’ve learned and apply it. IF you don’t already have Natural Dos products on hand, head over to our catalog and invest in your wellness through our carefully curated selection of edibles, oils, and capsules.

With a 100-day money bag guarantee, you can place your order with confidence and take the perfect CBDA dose for your unique needs!

References

Mateus M. Bergamaschi et al, “Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients”, Neuropsychopharmacology, 2011, May;36(6):1219-26. PMID: 21307846
Chandni Hindocha et al, “Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal”, Addiction, 2018, May 1;113(9):1696-1705. PMID: 29714034
Yasmin L. Hurd et al, “Cannabidiol for the reduction of cue-induced craving and anxiety in drug-abstinent individuals with heroin use disorder: A double-blind randomized placebo-controlled trial”, American Journal of Psychiatry, 2019, Nov 1;176(11):911-922. PMID: 31109198
Elizabeth A. Thiele et al, “Long-term cannabidiol treatment for seizures in patients with tuberous sclerosis complex: An open-label extension trial”, Epilepsia, 2022, Feb;63(2):426-439. PMID: 34957550